Only Project is a common umbrella for all projects supported by the Association Monégasque contre les Myopathies (AMM) via the funds raised from Only Watch and donations. AMM was launched in 2001 by a group of parents following the diagnosis of their children with Duchenne muscular dystrophy (DMD) with the aim of raising funds to accelerate research towards a cure for this rare genetic disease.  

DMD causes the progressive weakening of all muscles (including the heart), the loss of ambulation and global autonomy, and ending in premature death. It affects 1 in 3,500 boys, amongst them two Monégasque boys:  Paul Pettavino, and his friend and neighbor Philippe Ferreyrolles. Their diagnoses in 2000 led Paul’s parents Luc and Monique Pettavino to found AMM. 

Shortly after creating AMM, the founders met with other parents and researchers from around the world and their goal became clear: establish  a new stream of substantial funding for researchers to be able to explore therapeutic avenues. Only Watch – the biennial charity auction of unique watches – first took place in 2005 and has allowed AMM to fund very significant scientific and medical progress to the extent that a phase 1 clinical trial was launched in June 2023 to test a proprietary molecule, SQY51, thanks to the support of the charity.

➜ Get familiar with the research journey of the last 20 years and the subsequent funding strategy that was adopted in this letter to the Only Watch community by researcher Luis Garcia (Director of Research at CNRS, Director of the ENDICAP laboratory – UMR 1179 Inserm-University of Versailles-St-Quentin, UFR santé Simone Veil).

➜ 🎥 Look back on 20 years of history of our commitment with the film “The Story of Us”. 

Funds allocation strategy and decisions: an agile and potent partner for researchers. 

After years of organizing international roundtables and a large research program that financed projects led by scientists in universities around the world to refine the therapeutic avenues on DMD, the general strategy adopted by AMM has been to give priority support to the “Tricyclo-DNA” project: a technological breakthrough for which the AMM has provided itself, through Only Watch, the financial resources to support “from the laboratory bench to the patients“. As a result, in the past years, the Association’s funding has been distributed in majority to biotech organizations directly associated with  the charity and representatives of the families of patients. These biotech organizations have worked on the development of a drug that is currently being tested in a phase 1 clinical trial in France (more information on the trial here: clinical on 12 boys and young men. Although we remain cautious while waiting for outcomes, it is an achievement that we can collectively be proud of.  

This choice has never ruled out support for other projects, be they therapeutic alternatives, more fundamental research, or even research into diseases other than Duchenne muscular dystrophy but which could have an impact on Duchenne research. As a result, around 10% of the charity’s funds are allocated to grants as well as doctoral and post-doctoral fellowships for researchers in universities and hospitals internationally. This allows the scientific community to explore new therapeutic avenues without detracting from the overall strategy. 

On an operational level, teams requesting support may submit their projects to the AMM, which are then evaluated by its network of experts. There is no fixed call for tenders; the door is always open and processed on an ad hoc basis, with the aim of allocating funds as quickly as possible once a project has been selected. This has made us a particularly agile partner for researchers – in a field where response time is usually very long and hinders progress.

The attribution criteria that are evaluated with our community of researchers are: quality of the teams, interest of the projects in the strategic context as defined by the college of parents surrounded by the experts of their choice.

To be noted, for the past three years, a specific fund has been allocated via the FSRMM (Swiss Muscular Dystrophy Research Association) for doctoral and post-doctoral grants, jointly evaluated by the FSRMM scientific council and validated by the AMM.  

➜ List of projects supported by the Charity 2013-2023.
➜ Portraits of researchers supported by the charity. 

Management of funds for future developments. 

The financial resources required for current and future clinical developments are considerable, running into millions of euros and increasing at an exponential rate with each new phase. The association has adopted a conservative approach to spending the funds to make sure that it is in capacity to honor its commitment to the clinical developments that it is supporting and that necessitate very substantial means to go through, namely: following phases of the SQY51 clinical trial, development of the molecule for other exons of Duchenne muscular dystrophy (exons 16 and 44 are in preparation) as well as for other genetic diseases (research partnerships have been sealed on spinal muscular atrophy and epidermolysis bullosa), and the launch of new clinical trials testing the safety and efficacy of the molecules. 

Financial statements 2018-2022

Want to know more about how the charity funds are distributed and spent? Please find below the detailed financial statements of the AMM for years 2018 through 2022 as well as an activity highlight year by year for this period. We invite you to consult the more detailed versions of the accounts following the summarized versions, which are more informative and provide a fuller context.  

Please note that:  

☝️Only Watch being the charity’s biennial fundraising event, yearly “functioning expenses” vary significantly according to whether Only Watch takes place that year or not. Overall, they represent between 1 and 2% of funds raised.

☝️Only Watch taking place once every two years, usually in November, part of the auction proceeds are transferred by the auction house at the beginning of the following year and are therefore accounted for in the following financial statement.

☝️Funds distributed to biotechs that are working on a potential therapy (SQY Therapeutics, Synthena) appear as debts in the “Participating Interest” section for sums not yet abandoned. All sums advanced by the Association are intended to be waived. They are then transferred to the expenses account. 

At the occasion of the 10th edition of Only Watch and the beginning of a first safety phase trial launched thanks to the funds raised by our charity, the Association Monégasque contre les Myopathies has decided to create a new identity to regroup all projects it supports under one banner and a new, more international, colorful, modern identity:

The “Only Project”

As a reminder, the Only Project’s actions are focused on: 

  • Organizing key conversations (roundtables, collaborative and research programs) for researchers from around the world to share knowledge and accelerate breakthroughs;  
  • Financially supporting dozens of research projects with the goal of reaching and refining therapeutic outcome for DMD.

The logo, created by French designer Antoine Peltier with the charity’s team, is inspired by the shape of chromosomes and features a well-balanced set of colors each referencing an important component of this adventure: 

  • The “research” blue 
  • The “trustful” green
  • The “community” orange. 


Please refer to the page “Projects & Community” to learn more. 

In recent years, a significant part of our funds raised on Only Watch have been mobilized to set up a clinical trial for a therapy entirely developed by a biotech created with a consortium of parents and researchers and for which our charity is the main funder.  

The drug developed by SQY Therapeutics is called SQY51 and aims to treat patients affected by a deletion on exon (cutting unit of the gene) number 51 thanks to antisense oligonucleotides. In November 2022, french sanitary authorities greenlighted a clinical trial for SQY51. The first injections of the safety phase trial have just started at the Garches hospital, in the Paris region. 12 patients (boys of various ages) are to be included in the trial.

So, what to expect?

The first phase should last about 6 months. If there are no signs of toxicity, it will be followed by a second phase, focused on testing efficacy and understanding at what dosage the therapy works best for patients depending on their overall situation. 

All stakeholders have prepared this trial for it to be successful. But research is never as linear and simple as we want it to be. It is our duty to stay focused, keep a cool mind and prepare for different scenarios. 

If everything works well, it could lead to other trials for additional exons and other diseases. Indeed, as the dystrophin gene is one of the longest in the DNA, it represents an excellent case study and the solutions currently being tested could have numerous applications for many genetic diseases. As the technology developed is very promising, partnerships have already been sealed to test the technology on other diseases such as epidermolysis bullosa or spinal muscular atrophy. 

If, despite all the efforts made to ensure safety and effectiveness, this first trial was not conclusive, the process would be restarted at the laboratory research level with the aim to launch a second trial. Although it is not an exciting scenario, it is one that our organization is considering in order to be able to support the project in the long term. 

🎥 Learn more about the stakes and clinical trial (video shot in 2021)

A talk on research on Duchenne Muscular Dystrophy & upcoming clinical trials

Only Watch was born in 2005 with one intent: CREATE BEAUTY TO DO GOOD and more specifically to raise funds for research on Duchenne Muscular Dystrophy by auctioning one-off timepieces especially created for this occasion.

Since then, thanks to the constantly increasing formidable mobilization of the watch industry and the support of an entire ecosystem, this initiative has become a very awaited biennial rendezvous in the horology calendar for both brands and very generous collectors. 

The past nine editions have raised near to CHF/EUR 100 million which have given our Monaco-based charity organization the means to finance tens of grants and studies, support doctoral students and post docs, and dramatically accelerate research to now reach the clinical trials stage, while always preserving the virtuous, non-profit nature of its approach and cautiously keeping enough funds for the next phases to come. 

For this anniversary 10th edition excitement is, again, sky-high with creations already being crafted by the most established and sought-after brands and watchmakers as well as the new generation of promising independents – as it is now an Only Watch tradition to include a selection of the future of the high-end watch world.

As it has been the case since its origins, the Only Watch 2023 auction will take place under His Serene Highness Prince Albert II of Monaco’s high patronage, whose unwavering support has been essential to the success of this project that has put horology on the map of key contributors to research on neuromuscular diseases.

What to expect next?

  • List of participating brands, photos and specifications of the auctioned lots and world tour stops revealed June 29, 2023, 3pm (CEST) on
  • The world tour will run from beginning of September to beginning of November 2023.
  • The auction will take place in Geneva, at PALEXPO, and online on November 5,2023, at 2pm (Central European Time), under the hammer of Christie’s. 


More information on